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Introduction. Extracellular signal-regulated kinase 1/2 (ERK 1/2) is a serine/threonine protein kinase belonging to the mitogen-activated protein kinase (MAPK) family and is widely found in eukaryotic cells.ERK 1/2 plays a key role in signal transduction from surface receptors to the nucleus. Activated ERK 1/2 phosphorylates substrates in the cytoplasm or …